Prescription Drugs and Over-the-Counter Medications

Prescription drugs and over-the-counter medications touch nearly every American household, from the antibiotics a doctor prescribes to the pain reliever on a bathroom shelf. Multiple federal agencies share responsibility for this space: some decide which drugs can be sold and how they’re labeled, others oversee how much people pay and what insurance will cover, and still others police safety once a drug is on the market.

Paying for medication is often the first concern people have, since the price of a drug and what insurance actually covers can vary enormously. Prescription Drug Coverage explains how insurance plans and government programs decide what they’ll pay for, while Drug Costs and Assistance Programs covers efforts to lower what patients spend and the assistance options available when a needed drug is out of reach financially.

How drugs reach the market and stay there is governed by a separate set of rules. Pharmacy Regulation looks at who can dispense medications and under what conditions, and Drug Safety covers how new treatments are tested, approved, and monitored for problems after they’re in wide use.

Everyday practical questions come up too, like what to do with medications you no longer need. How to Safely Dispose of Prescription Drugs: “Take Back Day” Explained walks through safe disposal options that keep unused pills out of the wrong hands. Broader questions about how legitimate pain medications became linked to widespread misuse are addressed in Understanding Opioids: From Medical Use to Public Health Crisis.

An Independent Team to Decode Government

GovFacts is a nonpartisan site focused on making government concepts and policies easier to understand — and programs easier to access.

Our articles are referenced by trusted think tanks and publications including Brookings, CNN, Forbes, Fox News, Pew Research, Snopes, The Hill, and USA Today.

All Articles on Prescription Drugs and Over-the-Counter Medications

How to Safely Dispose of Prescription Drugs: “Take Back Day” Explained

American medicine cabinets hold a hidden danger. Expired, unused, and unwanted prescription medications become starting points for misuse, addiction, and…

Fentanyl in America: How a Medical Drug Became a National Crisis

Fentanyl, a synthetic opioid of extraordinary potency, stands at the center of an unprecedented public health crisis in the United…

How the FDA Approved OxyContin: The 1995 Decision That Started America’s Opioid Crisis

In December 1995, the U.S. Food and Drug Administration made a decision that would trigger decades of addiction, overdose, and…

How Making Pain the Fifth Vital Sign Triggered America’s Opioid Crisis

At the heart of the American opioid crisis lies a simple, powerful, and ultimately devastating concept: "Pain as the Fifth…

Understanding Opioids: From Medical Use to Public Health Crisis

Opioids are powerful drugs that interact with the human body to produce pain relief and other effects. Sometimes called narcotics,…

How Doctor-Prescribed Pills Created America’s Deadly Opioid Crisis

The American opioid crisis is a public health catastrophe that has claimed more than 800,000 lives between 1999 and 2023.…

Emergency Use Authorization: The FDA’s Crisis Playbook

When COVID-19 vaccines rolled out across America in December 2020, most people didn't realize they were receiving products that hadn't…

Understanding FDA Warning Letters and Safety Alerts

The Food and Drug Administration issues thousands of enforcement actions each year, from formal warning letters to urgent product recalls.…